BIF401 Assignment 2 Solution and Discussion

DEPARTMENT OF BIOINFORMATICS
& COMPUTATIONAL BIOLOGY
VIRTUAL UNIVERSITY OF PAKISTAN

Course: BIF401- Bioinformatics – I Term: FALL 2019
Instructor: Syed Hassan Abbas Assignment #2
Assigned Date: 04-11-2019 Due Date: 15-01-2020
Total Marks: 15

Note: There is one question having several steps. You are supposed to do your assignment by yourself. Any kind of plagiarism will be marked straight zero.
Question 1:
1- Take a candidate human gene amino acid sequence, preferably whose structure is not yet predicted.
2- Take the sequence of seven ortholog for same protein. (Like Mouse, rat, Chimpanzee etc.)
3- Make a phylogenetic tree after doing MSA (Multiple Sequence Alignment).
4- Predict the Secondary structure of the candidate gene amino acid sequence. (alpha helix, beta sheets, strands)
5- Predict the tertiary structure of the sequence.

Hint:
1- (Ortholog are genes in different species that evolved from a common ancestral gene by speciation. Normally, ortholog retain the same function in the course of evolution).
2- Use any of the tools available to you.