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    • BIF401 GDB 1 Solution and Discussion

      zareen

      Total Marks 5
      Starting Date Wednesday, July 15, 2020
      Closing Date Tuesday, July 21, 2020
      Status Open
      Question Title How bioinformatics help in drug discovery for COVID-19`
      Question Description

      Graded Discussion Board

      COVID-19 (SARS-CoV-2/Coronavirus 2019) is a world pandemic in which all most all the countries are affected. World Health Organization (WHO) has declared the coronavirus outbreak a global pandemic. One important step towards developing therapies against COVID-19 (SARS-Cov-2) is to understand its genomic makeup.

      In January, the genome sequence of SARS-CoV-2 was released to the scientific community. Since then, comparative genomics analyses have demonstrated that this novel virus belongs to the beta-coronavirus family and shared greater sequence homology to SARS-CoV than MERS-CoV. Unfortunately, there is still no specific antiviral treatment to either SARS-CoV or MERS-CoV.

      Point of Discussion:

      In light of this, how do scientists take advantage of the available genomic information of SARS-CoV-2 to better understand this novel virus and find cure for it? In short, How bioinformatics help in drug discovery for COVID-19?

      NOTE
      Your answer to the GDB should not more than 5 lines, in case found any answer exceed more than 5 lines will be rejected and grade 0 Marks.

      BIF401 - Bioinformatics I
    • An Introduction to Bioinformatics Resources

      A

      An Introduction to Bioinformatics Resources.pdf

      BIF401 - Bioinformatics I
    • BIF401 Handout

      A

      Please upload cogent format

      BIF401 - Bioinformatics I
    • BIF401 Assignment 2 Solution and Discussion

      zareen

      DEPARTMENT OF BIOINFORMATICS
      & COMPUTATIONAL BIOLOGY
      VIRTUAL UNIVERSITY OF PAKISTAN

      Course: BIF401- Bioinformatics – I Term: FALL 2019
      Instructor: Syed Hassan Abbas Assignment #2
      Assigned Date: 04-11-2019 Due Date: 15-01-2020
      Total Marks: 15

      Note: There is one question having several steps. You are supposed to do your assignment by yourself. Any kind of plagiarism will be marked straight zero.
      Question 1:
      1- Take a candidate human gene amino acid sequence, preferably whose structure is not yet predicted.
      2- Take the sequence of seven ortholog for same protein. (Like Mouse, rat, Chimpanzee etc.)
      3- Make a phylogenetic tree after doing MSA (Multiple Sequence Alignment).
      4- Predict the Secondary structure of the candidate gene amino acid sequence. (alpha helix, beta sheets, strands)
      5- Predict the tertiary structure of the sequence.

      Hint:
      1- (Ortholog are genes in different species that evolved from a common ancestral gene by speciation. Normally, ortholog retain the same function in the course of evolution).
      2- Use any of the tools available to you.

      BIF401 - Bioinformatics I

    BIF401 Assignment 2 Solution and Discussion

    BIF401 - Bioinformatics I
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    • zareen
      zareen Cyberian's Gold last edited by

      DEPARTMENT OF BIOINFORMATICS
      & COMPUTATIONAL BIOLOGY
      VIRTUAL UNIVERSITY OF PAKISTAN

      Course: BIF401- Bioinformatics – I Term: FALL 2019
      Instructor: Syed Hassan Abbas Assignment #2
      Assigned Date: 04-11-2019 Due Date: 15-01-2020
      Total Marks: 15

      Note: There is one question having several steps. You are supposed to do your assignment by yourself. Any kind of plagiarism will be marked straight zero.
      Question 1:
      1- Take a candidate human gene amino acid sequence, preferably whose structure is not yet predicted.
      2- Take the sequence of seven ortholog for same protein. (Like Mouse, rat, Chimpanzee etc.)
      3- Make a phylogenetic tree after doing MSA (Multiple Sequence Alignment).
      4- Predict the Secondary structure of the candidate gene amino acid sequence. (alpha helix, beta sheets, strands)
      5- Predict the tertiary structure of the sequence.

      Hint:
      1- (Ortholog are genes in different species that evolved from a common ancestral gene by speciation. Normally, ortholog retain the same function in the course of evolution).
      2- Use any of the tools available to you.

      1 Reply Last reply Reply Quote 0
      • zareen
        zareen Cyberian's Gold last edited by

        BIF401_Assignmnet_02_Solution_Fall_2019.pdf

        1 Reply Last reply Reply Quote 0
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