Total Marks 5
Starting Date Wednesday, July 15, 2020
Closing Date Tuesday, July 21, 2020
Question Title How bioinformatics help in drug discovery for COVID-19`
Graded Discussion Board
COVID-19 (SARS-CoV-2/Coronavirus 2019) is a world pandemic in which all most all the countries are affected. World Health Organization (WHO) has declared the coronavirus outbreak a global pandemic. One important step towards developing therapies against COVID-19 (SARS-Cov-2) is to understand its genomic makeup.
In January, the genome sequence of SARS-CoV-2 was released to the scientific community. Since then, comparative genomics analyses have demonstrated that this novel virus belongs to the beta-coronavirus family and shared greater sequence homology to SARS-CoV than MERS-CoV. Unfortunately, there is still no specific antiviral treatment to either SARS-CoV or MERS-CoV.
Point of Discussion:
In light of this, how do scientists take advantage of the available genomic information of SARS-CoV-2 to better understand this novel virus and find cure for it? In short, How bioinformatics help in drug discovery for COVID-19?
Your answer to the GDB should not more than 5 lines, in case found any answer exceed more than 5 lines will be rejected and grade 0 Marks.
DEPARTMENT OF BIOINFORMATICS
& COMPUTATIONAL BIOLOGY
VIRTUAL UNIVERSITY OF PAKISTAN
Course: BIF401- Bioinformatics – I Term: FALL 2019
Instructor: Syed Hassan Abbas Assignment #2
Assigned Date: 04-11-2019 Due Date: 15-01-2020
Total Marks: 15
Note: There is one question having several steps. You are supposed to do your assignment by yourself. Any kind of plagiarism will be marked straight zero.
1- Take a candidate human gene amino acid sequence, preferably whose structure is not yet predicted.
2- Take the sequence of seven ortholog for same protein. (Like Mouse, rat, Chimpanzee etc.)
3- Make a phylogenetic tree after doing MSA (Multiple Sequence Alignment).
4- Predict the Secondary structure of the candidate gene amino acid sequence. (alpha helix, beta sheets, strands)
5- Predict the tertiary structure of the sequence.
1- (Ortholog are genes in different species that evolved from a common ancestral gene by speciation. Normally, ortholog retain the same function in the course of evolution).
2- Use any of the tools available to you.